Such work can translate to drug discovery leads.
Computational Biophysics of the Skin - CRC Press Book
The other side to biophysics is more theoretical. Klaus Schulten , director of the theoretical biophysics group at the University of Illinois, Urbana-Champaign, and self-proclaimed "world champion of biological simulations," says that biophysicists work to describe the matter in cells and how they carry out their functions.
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Structure-based approaches to drug design have helped fuel theoretical biophysics, according to Brian Shoichet , associate professor of molecular pharmacology and biochemistry at Northwestern University. Some will argue, however, that such biological simulations become studies in other fields: "I wouldn't consider clinical simulations biophysics, because you start to step away from the physics and more toward physiology," Alvarez says. Other biophysics tools aid in drug discovery.
Molecular simulations are often performed in silico computer-based to predict toxicity, side effects, and ligand metabolism. This grant transfers leadership of the New York Structural Genomics Research Consortium to Structural Genomix, which in turn will provide access to its state-of-the-art X-ray beamline facility for high-throughput X-ray crystallography capability. The grant to Structural Genomix is one of the largest in protein-structure research, and Shoichet says the money available in biophysics compares favorably to resources for traditional fields like chemistry.
The National Institutes of Health tends to fund at a higher rate than pharmaceutical companies do. The Biophysical Society also provides fellowships for research.
The objective of this chapter is to review the main biomechanical and structural aspects associated with both intrinsic and extrinsic skin ageing, and to present potential research avenues to account for these effects in mathematical and computational models of the skin. This will be illustrated through recent work of the authors which provides a basis to those interested in developing mechanistic constitutive models capturing the mechanobiology of skin across the life course.
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A computational insight into skin formation
Constitutive modelling of skin ageing. Abstract The objective of this chapter is to review the main biomechanical and structural aspects associated with both intrinsic and extrinsic skin ageing, and to present potential research avenues to account for these effects in mathematical and computational models of the skin.
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